The rotator cuff musculature imparts dynamic stability to the glenohumeral joint. In particular, the balance between the subscapularis anteriorly and the infraspinatus posteriorly, often referred to as the rotator cuff "force couple," is critical for concavity compression and concentric rotation of the humeral head.


Our goal was to determine the effect of pentadecapeptide BPC 157 on rotator cuff tear injury in rat model. 48 rats underwent detachment of the supraspinatus and infraspinatus and were randomly assigned to control and pentadecapeptide BPC 157 group.


BPC 157 animals were regularly treated with pentadecapeptide BPC 157 (10µg/kg) intraperitoneally, control animals got equivalent volume of saline. Animals were observed during experiment and were sacrificed 2, 4, 8 and 12 weeks after the surgery.


Macroscopic observation (muscle atrophy (m(non-operated m triceps)/m-operated(m triceps)), movement range, front leg length) and functional analysis (walk pattern (SFI), front limb muscle strength (weightlifting time) were performed.


In animals treated with pentadecapeptide BPC 157 was observed total functional recovery similar to healthy animals, along with supraspinate and infraspinate tendon healing. In controls, mobility rage, muscle strength, and leg length were reduced compared to pentadecapeptide BPC 157 treated animals.


In conclusion, pentadecapeptide BPC 157 could be successfully used in healing and functional recovery of rotator cuff tear injury.



Grant Funding Source: Supported by Grant 108-1083570-3635, Ministry of Science, Education and Sports, Croatia


  1. 1Pathology School of Medicine, University of Zagreb Zagreb Croatia

  2. 2Pharmacology School of Medicine, University of Zagreb Zagreb Croatia

  3. 3Surgery School of Medicine, University of Zagreb Zagreb Croatia

  4. Clinic for Surgery, Orthopaedics and Ophthalmology Veterinary Faculty, University of Zagreb Zagreb Croatia

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