Fladrafinil vs Modafinil & Adrafinil


Another name for Fladrafinil is fluorafinil and its chemical designation is CRL - 40 941. It is classified as an eugeroic and its action promotes wakefulness. It is very similar in its composition and effects to modafinil and adrafinil. However, it also induces an anti-aggressive response whereas these two similar drugs do not.

On a chemical level, Fladrafinil is an adrafinil derivative, specifically a bis(p-fluro) ring-substitute. Effects additional to enhanced wakefulness include quickened cogitation. Fladrafinil also boosts neural functioning, increases recollection, and heightens ambition. It achieves these effects by activity related to histamine and dopamine neurotransmitters.

Fladrafinil is known to have minor to zero side effects, provided the recommended dosage and frequency are adhered to over a limited span of time. This drug should is NOT intended for extended usage.

Fladrafinil is three to four times more effective than adrafinil. It is recommended that when beginning treatment with Fladrafinil, an introductory dose between thirty to eighty mgs be consumed over fourteen to sixteen hours.

By comparison, such a dosage is considered moderate in the case of adrafinil. The introductory dose of Fladrafinil should be gradually scaled up as the system demonstrates acceptance of the drugs.

However, the maximum dose should never be greater than two hundred mgs daily.

Warning: the above information has not been approved by the FDA. The drug is not provided for purposes of diagnosis, treatment, prevention or curing of any symptoms or disease.

If you suffer from any ailment, always consult a medical professional before using Fladrafinil or any other medication. Do not continue the use of Fladrafinil without a further medical consultation if you experience any side effects.


Fladrafinil or fluorafinil, less commonly known as fluoromodafinil or CRL - 40 941, is classed as a synthetic eugeroic or smart drug. It is very similar in its chemistry and effects to modafinil and adrafinil. In fact, it’s essentially the same substance but for the addition of a single molecule of fluoride. This addition greatly enhances its effects by making it easier for the body to absorb.

The fluoride molecule explains the names fluorafinil and fluoromodafinil.

The drugs function is that of an eugeroic; that is, a drug which boosts wakefulness. The effects should be very familiar to any user of adrafinil or modafinil. Its action excites various neurotransmitters, such as histamine and dopamine.

This is considered a safer pathway than alternative stimulants, such as amphetamines, which also have the potential for addiction.


Positive Effects of Fladrafinil, also known as Fluorafinil, Fluoromodafinil or CRL - 40 941.

Notable positive effects of Fladrafinil include enhanced recollection, greater mental clarity, increased ambition and an all-round higher level of mental performance. As it improves focus, it may be of use in treating conditions such as ADHD, Alzheimer’s and depression. It also has great application in the treatment of sleeping disorders, such as insomnia or narcolepsy.

Fladrafinil is generally prescribed at a potency of between thirty to one hundred mgs daily. The upper limit dose is two hundred mgs in a day and this must never be exceeded. Side effects are rare when the drug is taken according to these instructions and over the short-term only.

The most commonly reported symptoms are headaches, hyperactivity, irritability, disorientation, stomach complaints and vasoconstriction.


Fladrafinil, otherwise known as CRL - 40 941 or fluorafinil, is a eugorics drug, which means one that increases wakefulness. It is highly similar, in both its chemistry and effects, to the drugs modafinil and adrafinil, both of which were first formulated in the ‘70s.

Fladrafinil is classed as a nootropic, a type of drug known colloquially as a “smart drug,” and used to enhance brain function. Fladrafinil not only boosts wakefulness but also memory function, focus and motivation. It is also several times more potent than either modafinil or adrafinil.


Fladrafinil was initially formulated in the 70’s as part of a range of related substances. Its calmative properties were noted and it was soon being tested in rats and humans. Such tests confirmed it to have roughly double the potency of adrafinil.

The drug has since accrued a positive reputation, however it’s still not available for general purchase over the counter.

Instead, it is usually purchased online as a research chemical rather than a pharmaceutical.

Positive effects

Fladrafinil serves the same intended function as adrafinil; to keep people alert and awake. This nootropic is also known to boost focus and lower tiredness, affording its users greater productivity.

The major benefit of Fladrafinil over similar drugs is its greater potency. It has been demonstrated to be at least twice as potent as adrafinil. It’s an excellent choice therefore is your system develops tolerance to adrafinil or other, similar drugs. During its development, it was noted that Fladrafinil may serve to reduce aggression.

For the treatment of hyperactivity disorders, such calmative properties may well have a synergistic effect with the greater focus the drug promotes.


There are no documented cases of major side effects occurring as a result of using Fladrafinil according to prescription. One of the oft-reported minor side effects is that the drug imparts a particular fragrance to one’s urine. It has also been established that the drug may cause narrowing in the blood vessels, a condition known as vasoconstriction.

Some reports to be found online state these side effects outweigh the drug’s usefulness. There is as yet no clinical evidence that such effects arise from use of Fladrafinil.


Flmodafinil well-known that the chemical composition of adrafinil and Fladrafinil are nearly identical. The distinguishing factor is that Fladrafinil has one of its molecular rings altered. This minor change is enough to greatly increase the drug’s bio-availability, or the rate at which the body can absorb the substance. This change is enough to greatly enhance its potency.

Like adrafinil, it’s also classed as a eugoric, in other words a drug which boosts alertness and combats the urge to sleep. Animal trials have shown the drug to lower aggression but this must still be borne out with human trials.


The most common uses of Fladrafinil mimic those of Adrafinil, Modafinil and related drugs. It is often take by users of those substances who have developed tolerance to them over time.

The prescribed use of the those drugs is in the treatment of sleeping disorders such as insomnia or narcolepsy. Fladrafinil is also highly effective for these purposes. It may also be taken off-label by those wishing to improve their work or study performance, due to its ability to increase focus, memory and general mental performance.

The drug may also be helpful for sufferers of ADHD, as it increases focus and has a calmative effect.


User reports on Fladrafinil are fairly varied, with some reporting major benefits and others remaining unconvinced of its usefulness. Many people have stated that this nootropic increases their work or academic performance due to its effects on concentration, memory and mental alertness.

It’s also been reported that the drug’s effects are only mild, comparable to a regular cup of coffee.

There is apparently uncertainty in certain quarters as to the drug’s ability to stave off the need for sleep. However, in all cases, there is agreement that effects vary based on dosage.

Some small proportion of users also reported that the drug exacerbated their anxiety or disordered their sleep cycle. It is also fairly common to see Fladrafinil associated with reports of elevated blood pressure.


Using Fladrafinil for a short period should produce several noticeable effects. Such effects include enhanced focus, mental clarity and alertness. The user experience is often compared to caffeine, although without the accompanying “jitters.”

On the negative side, short-term usage may lead to increased blood pressure and this should be monitored in those with already high blood pressure.

Prolonged usage

Using Fladrafinil continuously for more than a couple of weeks is not recommended.

However, the longer term effects are said to include a calming effects, in addition to the expected benefits reported by short-term users. One notable side effect of long-term usage is constriction of the blood vessels. It seems from user reports that tolerance either does not develop or takes a very long time

to do so.

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